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Abstract
The present study was performed to investigate the biochemical effect of three natural antitumor agents, green tea beverage, black seed powdered seeds and turmeric powdered rhizome in relation to rat liver injuries induced by DEN with PB. A number of 96 adult male albino rats were used in this study, and grouped into 4 groups arranged as follows:
(A) Control group
Contains 24 rats, received basal diet and water all over the experimental period.
(B) Green tea beverage-treated group
Contains 24 rats, received basal diet and 1% green tea beverage-containing water all over the experimental period.
(C) Black seed powdered seeds-treated group
Contains 24 rats, received 2% black seed powdered seeds-containing diet and water all over the experimental period.
(D) Turmeric powdered rhizome-treated group
Contains 24 rats, received 4% turmeric powdered rhizome-containing diet and water all over the experimental period.
After 2 weeks (from start of the experiment), 1st 6 blood samples of 6 rats from each group were collected, these 6 rats were scarified and liver samples were taken. Afterwards, induction of liver injury (to the remained 18 rats in each group) was done by using single 0.5 mIT/P injection of DEN (200 mg/kg B.wt.) dissolved in 0.9% NaCl solution. After 4 weeks (from start of the experiment), rats were received sodium salt of PB in their drinking water (600 p.p.m.) till the end of the experiment. After 2, 4 and 6 months (from start of the experiment), 2nd, 3rd and 4th blood and liver samples were taken respectively. The obtained results were statistically analysed, and can be summarized as follows:
(1) Green tea beverage treatment
1. Significant increase in rat B.wt. in treated carcinogens group compared with carcinogens group at 2 and 6 months after treatment.
2. Significant increase in rat liver weight in treated carcinogens group compared with carcinogens group at 2, 4 and 6 months after treatment.
3. Significant decrease in serum AFP in treated carcinogens group compared with carcinogens group at 2, 4 and 6 months after treatment.
4. Significant decrease in serum ALT enzyme in treated carcinogens group compared with carcinogens group at 2, 4 and 6 months after treatment.
5. Significant decrease in serum AST enzyme in treated carcinogens group compared with ccarcinogens group at 4 and 6 months after treatment. Also, significant decrease in serum AST enzyme after two weeks compared with control group.