الفهرس 
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Abstract
Diabetes mellitus is a common chronic disorder and represent a serious health care challebge. It greatly increases the risk of coronary heart disease,notably atherosclerosis.Studies have shown that the mortality rates due to coronary artery disease and cerebrovascular disease are at least doubled in diabetics compared with non-diabetic individuals.Existing therapies such as sulphonylureas,metformin and thiazolidinediones can significantly reduce blood glucose level and hence,microvascular complication of diabetes mellitus However,it is believed that there is an inevitable deterioration in glycaemic control in the long term. so , it appears that more than just good glycaemic control is necessary to minimize the microvascular and macrovascular complication that lead to the development of atherosclerosis.Flavonoids have been shown to posses several therapeutic properties, many of wich may be related to their antioxidant and free-radical-scavenging ability . The flavonoid quercetin QRT is reported to exhibit the highest antiradical property toward hydroxyl and peroxyl radicals and superoxids anions ,a mechanism involved in developing atherosclerosis. It could be found in onions , apples, green and black tea. However, quercetin may not present naturally in sufficient quantities to show a therapeutic result.The objective of this study was to investigate the feasibility of combining hypoglycemic , orally administered agents with quercetin in an attempt to add the benefits of using the flavonoid to the therapeutic effect of the hypoglycemic agent . The main emphasis of the work was to keep the therapeuyic characteristic of the tested hypoglycemic agents unaffected.