الفهرس 
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Abstract
C. albicans is a yeast like fungus commonly present in the throat, vulvovaginal area, skin and intestine. When something happens to Upset the normal balance of body flora for e.g. prolonged antibioties therapy, debilitating illness with lowered resistance, malignancy, lupuseryth-ematesus, diabetes meltitus, tuberculosis treatment with corticosteroids or cytotoxic drugs and so forth, the yeast may proliferate and cause an infection. It can cause a wide variety of disorders including: Thrush which is observed in infants, whose mothers have vaginal candidosis and in elderly patients under antibiotics or steroid therapy. The disease is characterized by white creamy patches seen on the mucous membranes and corners of mouth, white to gray pseudomembreanes may cover the tongue. Vaginal candidosis which is common complaint among women and can be sexually transmitted. The disease is characterized by the present of thick yellow, milky discharge and patches of graywhite pseudomembranes on the vaginal mucosa, and the patient usually present with vulval itching and soreness. Cutaneous candidosis it may be localized to one area in the skin e.g axilla, in the groin or perianeal area, and between the toas. Diabetics or individual whose Job require frequent immersion in water as dishwashe are particulary susceptible. Condidosis of the nail: c. albicans produce a thickening and hardening, grooving, pitting or erosion of the nail material often the skin around the nail is also involved. They occur most frequently in persons whose hands are regularly immersed in water. Systemic candidosis which infect many organs like alimentary tract, kideny, urinary bladder, lung,heart,.. .etc Bronchopulmonary candidosis this disease is mainly observed as secondary infection resulting from antibiotic treatment for bacterial pulmonary disease. The patient has an irritating cough and produces mucoid sputum. Intestinal usually by prolonged predisposed candidosis antibiotics treatment which destroys the normal bacterial flora and allows candida to establish infection. The first step in treatment of candidosis is to eliminate the predisposing factors, if possible in particular to stop or change antibacterial therapy. Nowadays the treatment of candidosis is much facilitated by using the antifungal drugs e.g Amphotericin B, imidazole group of drugs (clotrimazole, MCZ, econazole and others). .G albicans is generally regarded as highly resistant to all antibacterial combination same of the antibiotics, but antibacterials with antifungal agents give synergistic activity against C.albicans. Thus it would be interesting to evaluate the senstivity of some antibacterial and antifungal agents (tetracycline, chloramphenicol, MCZ and nystatin and their combination in pairs against isolales of (.albicans. Thirty hundreds and eight samples were obtained from different sources (mucocutanous lesion, oral swabs, vaginal swabes and environmental samples). In addition, 33 isolates from systemic candidosis were supplid under the courtesy of Dr. Mona Warda (Alex. university. Hospital) All samples were subjected to: 1) Direct microscopic examination by KOH. 2) Culture on the following media: a) Sabouraud’s dextrose agar with cyclohexamide. b) Yeast extract malt extract agar (for environ mental samples only) 3) Identification of the isolated k albicans by: a) Germ tube formation b) Chlamydospore production c) ApI20C . 4) All h al bic an s isolates were tested for their sensitivity to Tetracycline, chloramphenicol, MCZ and Nystatin and their combination in pairs. 5) All tests of antibacterial and antifungal agents were proformed usmg tube to dilution methods determine the lowest concentration of the drug to inhibit clearly visible growth (MIC) after incubation at 30 Co for 24 hours and 48 hours and to determine the lowest concentration from which subcultures are negative or yield fewer than 3 colonies (MFC) the antibiotics were diluted from 20 to 0.01 Ug/mL and antifungal were diluted from 100 to 0.005 U g/mL ) 6) Different media were used such as a) Unbuffered Yeast Nitrogen base broth for testing with tetracycline, chloramphenicol, MCZ and combination each other. b) Antibiotics medium No #3 was used for tests of nystatin and its combinaction with tetracycline and chloramphenicol.