الفهرس 
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Abstract
This study highlights the potential of using bcl-2 immunoreactivity in combination with Dukes’stage as a means of predicting favourable prognosis in CRC. A novel observation of dense nuclear localisation of chromatinassociated bcl-2 and bax protein expression in morphologically identifiable apoptoyic cells and bodies in clinical and cell line materials was confirmed using WB, CLSm and 3-D reconstruction in cell line models. The staining range of bcl-2 protein family members should be extended to the nuclear compartment of human tumour cells which may have a functional role in apoptosis particulary in CRC.