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Abstract
Acute leukemias are the malignancies of immature hematopoietic cells.They are characterized by accumulation of blast cells in the bone marrow, peripheral blood and other tissues, with suppression in hematopoietic function. Acute leukemias are broadly divided into myeloid and lympoid categories, based on the cell origin. Myeloid and lymphoid leukemias differ from one another as regard to clinical presentation, course and response to therapy. The incidence rate of acute leukemias is greater in developed countries and in industrialized cities. Acute myeloid leukemia (AML) is more common in males than in females. The difference is even more apparent in older patients. However, the disease affects all age groups. Acute lymphoblastic leukemia (ALL) is the most common type of leukemia in children. In adults, it is less common than AML.Matrix metalloproteinases (MMPs) are a family of endopeptidases excreted by a number of cell types. In spite of the great diversity in domain structures, MMPs have characteristic features. They are able to hydrolyze the protein or proteoglycan component of the extracellular matrix, contain• calcium and zinc ions necessary for catalytic activity, are excreted as a latent activatable protein and they can be inhibited by their natural inhibitors, the tissue inhibitors of matrix metalloproteinases.