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Abstract The present study comprised 100 patients with recurrent aphthous ulcers and 20 healthy control persons their age ranged between 16 and 70 years with a mean age of 25 years. They were subjected to the followings : - History interrogation. - Clinical examination. - Laboratory investigations (stool examination, urine examination, measurement of pH of saliva, complete blood cell count, kidney function tests, liver function tests, serum ferritin level measurement, estimation of total iron binding capacity , hepatitis markers (HCVAb and HBs Ag), polymerase chain reaction for hepatitis C, cytomegalovirus antibodiy (IgM Ab), HIV antibody, pathological examination for ulcers, upper endoscopy, and colonoscopy. from the present study, we concluded the followings : - Females were more commonly affected than males by about 7:3. 128 - The common age affected was 20 - 40 years and then the percentage of the ulcers declined. The prevalence of the ulcers tends to be higher in mental workers (about 76% in all investigated patients). Also, about 15 % of these patients exposed to different types of stress. - Recurrent aphthous ulcers were more common in non smokers. - Recurrent aphthous ulcers were not related to menstrual cycle in the investigated patients. - Recurrent aphthous ulcers showed higher incidence in those with bad dental hygiene than with good dental hygiene. - Recurrent aphthous ulcers were related to trauma of the mouth (13%). - Recurrent aphthous ulcers were not related to type of the food intake in the investigated patients. - The pH of saliva in patients with RAU was more acidic than in control subjects. - Recurrent aphthous ulcers were associated with chronic gastritis and or duodenal ulcers in 27% of the patients. |