الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
In the search for bioactive compounds from marine sponges, this study led to the isolation of 15 compounds, six of which are new metabolites. The sponges used in this study were Suberea mollis and Pseudoceratina arabica and were collected from the Egyptian Red Sea coast.
A Combination of different chromatographic techniques was used for purification of the compounds. The structural determination of the isolated compounds was performed by study of their physical and spectroscopic data including UV, 1D and 2D NMR studies, as well as high-resolution mass spectral data.
1. The sponge Suberea mollis:
The extract of the sponge Suberea mollis afforded nine compound including four new metabolites. The compounds were identified as subereamolline A (1, new), subereamolline B (2, new) aerothionin (3), homoaerothionin (4), 11,19-dideoxyfistularin-3 (5), aeropysisnin-1 (5), subereaphenol B (7, new), aeroplysinin-2 (8), subereaphenol C (9 , new). The compounds were evaluated for determination of their antimicrobial, antioxidant and antitumor activities.
The structures of the isolated compounds and their biological activities were listed in Table 47.
2. The Sponge Pseudoceratina arabica:
The extract of the sponge Pseudoceratina arabica afforded nine compounds including three new metabolites. The compounds were identified as cholesterol (10), moloka’iamine (11), hydroxymoloka’iamine (12, new), ceratiamine (13), 5-bromo-2,3-dihydroxy-6-methoxybenzaldehyde (15), ceratinophenol A (16, new), molokiaketamide (17, new) and psammaplysin-A (18). In addition, only a partial proposed structure for compound 14 was assigned according to the available data. The compounds were evaluated for determination of their antimicrobial and antitumor activities and their activities on the intestine and mammalian heart. The structures of the isolated compounds and their biological activities were listed in Table 48.