الفهرس 
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Abstract
AT III is a major inhibitor of serine active proteases of the coagulation cascade. It plays an important role in the inactivation of thrombin and factor Xa.
Appropriate anticoagulation induced by heparin is a fundamental requisit for heart surgery with cardiopulmonary bypass (CPB). The antithrombotic effect of heparin is closely related to the presence of AT III as cofactor. That is to say, AT III is essential for the anticoagulant effect of heparin.
The fall in plasma AT III levels is associated with deep venous thrombosis, pulmonary embolisation, nephrotic syndrome,chronic liver disease, disseminated intravascular coagulation (DIC) and with oral contraceptive usage. The decrease in AT III is established as a diagnostic criteria for the early diagnosis of DIC. The return to normal or near normal of post-treatment AT III levels may be a highly useful index in assaying the efficacy of therapy in patients with DIC.
In this study plasma AT III concentration and activity in selected 32 patients undergoing cardio-thoracic operation with CPB were estimated. It was estimated pre & post-operatively using radial immunodiffusion method for AT III concentration and the chromogenic substrate method for the activity. Their results showed significant reduction of concentration and activity after bypass producer.