الفهرس | Only 14 pages are availabe for public view |
Abstract Inhalational anaesthetics play an essential role in paediatric anaesthesia. Halothane has been used for paediatric anaesthesia for many years although it has some disadvantages like myocardial depression, dysrrhythmia, significant degree of metabolism, and the rare but serious complications of hepatitis so, there is a need for asafer inhalational anaesthetic more suitable for children. Sevoflurane is a new fluorinated ether with many favorable properties as non-flammability, also low blood/ gas partition coefficient allowing for rapid induction of and recovery from anaesthesia. It has a pleasant, non-irritant odor that makes it more acceptable to children. Sevoflurane is characterized by cardiovascular stability, safety in ischaemic heart disease, preservation of regional blood flow, minimal respiratory depression, safety on the liver, as it does not affect hepatic perfusion, oxygenation, or metabolic function. In addition it is not potentially hepatotoxic like halothane as it is metabolized to Hexafluoroisopropanol (HFIP) and not to Ttifluoro-Acetic acid (TFA). On the kidney no reported cases of renal troubles though fluoride produced from its metabolism, however there is controversy about this |