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Abstract Net-oen and DMPA are the two most commonly used injectable contraceptive agents there has been somediscussions in the literature regarding the site of gonadotrophin inhibiting action of these injectable contraceptives evidence has been presented indicating that gonadotrophin inhibition occurs primarily at the level of the hypothalamus or at the pituitary however most of the reported studies have been limited to the study of LH and FSH release following stimulation with LHRH or some other hypophysiotrophic releasing hormone the present work aimed at studying the effect of long term use of DMPA and Net-OEN on the response of the pituitary to LHRH as evaluated by the serial measurement of serum levels of FSH $LH . thirty two female volunteers were chosen for this study in three groups . |