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العنوان
Design and Synthesis of Some Novel Quinoline Derivatives of Biological Interest
الناشر
Alexandria University. Faculty of Pharmacy. Department of Pharmaceutical Chemistry,
المؤلف
Rizk, Ola Hassan
هيئة الاعداد
باحث / علا حسن رزق
مشرف / سامى احمد شمس الدين
مشرف / السيدة محمد احمد
مشرف / منى احمد مهران
تاريخ النشر
2007 .
عدد الصفحات
129p.
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
الصيدلة ، علم السموم والصيدلانيات
تاريخ الإجازة
1/1/2007
مكان الإجازة
جامعة الاسكندريه - كلية الصيدلة - Pharmaceutical Chemistry
الفهرس
Only 14 pages are availabe for public view

from 164

from 164

Abstract

It is well documented that quinolines, fused quinolines as well as quinolines linked to other heterocyclic rings possess broad spectrum of biological activities, especially antimicrobial activity. These facts initiated the design and synthesis of novel quinoline derivatives joined to various heterocyclic moieties such as thiadiazoles, triazoles and oxadiazoles and studying their antibacterial and antifungal activities.
The present thesis is divided into the following chapters:

Presented a brief survey on the recent researches on the antimicrobial activity of quinoline, thiadiazole, triazole and oxadiazole derivatives. Structure activity relationship is presented whenever possible.
Research objectives:
It delt with the aim of the present work together with the rationale upon which the newly suggested compounds have been designed and synthesized.
Discussion:
In this chapter, the theoretical concepts of the methods adopted for the synthesis of the designed compounds are discussed with reference to the knowledge available in the literature. Structures of some representative examples of the newly synthesized compounds were elucidated by interpreting their IR, 1H-NMR and 13C-NMR spectra.
Experimental:
It described the detailed practical procedures adopted for the synthesis of the intermediate and final compounds. Structures of some representative examples of the newly compounds prepared in this work were confirmed by elemental microanalyses, IR, 1H-NMR and 13C-NMR.