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Abstract Alpha thalassemia is the most common single gene disorder world wide . The genetic defect in alpha thalassemia are characterized by the decrease or complete suppression of alpha globin polypeptide chain synthesis . The most frequent underlying cause of this group of disorders is the deletion of one or more of the normal complement of four alpha globin genes . Population surveys have shown that - 3.7 and - 4.2 alleles are predominant in North African and Mediterranean area . |