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Abstract
Thrombosis in the background of plaque rupture or fissure increasingly recognized as pivotal event in the pathogenesis of acute coronary syndrome not only acute myocardial infarction, but also in the syndrome of unstable angina/ non-ST elevation myocardial infarction.
Early reperfusion of the ischemic myocardium by thrombolytic agents is effective in reducing mortality from acute myocardial infarction. However, better results including further reduction in mortality and recurrence of ischemia can be achieved with direct percutaneous transluminal coronary angioplasty.
Percutaneous coronary intervention (PCI) is an effective treatment for myocardial ischemia in patients with coronary artery disease. More than one million PCI procedures were performed worldwide in 1998. Combined pharmacologic intervention, and primary angioplasty and/or stenting are needed to further enhance our decision-making process and improve therapeutic outcomes in the patient with AMI.