الفهرس 
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Abstract
The role of histamine in the stimulation of gastric acid secretion has for many years been a subject of considerable interest and controversy, having engaged many of the most outstanding gastroenterologists in this century.
The participation of certain brain areas specially the hypothalamus and related limbic structures, in the regulation of gastric secretion has been documented. Several brain compounds that affect gastric secretion -as histamine- upon central administration also have been described.
The aim of the present work was to determine the type of histamine receptors involved in the gastric secretory process in addition to finding out the role of the vagus nerve in the control of gastric acid secretion.
The present study was carried on 280 albino rats, all of which were subjected to cannulation of the lateral brain ventricle under light ether anaesthesia. Three days after cannulation the rats were divided into the following groups.
GI : consisted of 20 rats and served as controls. Gil : consisted of 60 rats whichreceived three different ICV doses of histamine 25 ug/kg (A), 50 ug/kg (B) and 100 ug/kg (C).