الفهرس 
ACKNOWLEDGMENT
Gastroduodenal mucosal integrity and peptic ulcer diseaseOnly 14 pages are availabe for public view
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Abstract
Platelet-derived-endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/dThdPase) is a potent angiogenic peptide. It’s pathophysiological role is still not well clarified, however, it can act on endothelial, epithelial cells, fibroblast, monocytes, macrophages (stromal cells) inducing their proliferation, migration, cell restoration and inducing angiogenesis, helping the healing process of gastroduodenal disorders.
Gangliosides (Gs) are considered as promoters of angiogenesis i.e. promoto vessel morphogenesis, while nitric oxide (NO) has a double edged sword, where its effect may depend on No concentration and response of target tissue. It can have an anti-inflammatory effect by enhancing mucosal blood flow through vasodilatation effect, thus preserving the gastroduodenal mucosal integrity, but it can exert, in excess amount, a proinflammatory effect leading to gastromucosal injury.
The Aim of this study is to evaluate the serum tissue concentration of PD-ECGF/dThdPase, gangliosides, nitric oxide in various gastroduodenal disorders and to determine whether these indices have a relation with H.pylori infection.
The present study demonstrated that serum and tissue levels of PD ECGF/dThdPase, gangliosides, nitric oxide are significantly high in patients with gastritis and duodenitis, more higher in DU, GU. The highest levels were observed in gastric cancer patients compared to controls and other groups. These biochemical indices are significantly higher in cases with H.pylori infection than non infected cases.