الفهرس 
acknowledgmentOnly 14 pages are availabe for public view
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Abstract
The proper therapy for bleeding gastroesophageai varices, secondary to noncirrhotic, portal vein thrombosis, represents a problem. Disparity of opinions exists regarding the significance of hepatic portal blood flow and the consequences of total portal-systemic shunts in this condition. The physiological goal of maintaining portal venous perfusion after distal splenorenal shunt (DSRS) seems to be best achieved in these patients.
The aim of the present work was to study the effect of the DSRS of Warren on the liver in dogs with extrahepatic portal block. The present study was carried out on 20 dogs. The dogs were divided into two groups (10 animals each). Thiopental sodium was used as a sole anaesthetic. Over wedged biopsies were taken at the first session to be used as control and the pressure in the portal vein was measured by direct puncture using central venous pressure (CVP) saline manometer to be considered as a baseline. At the same session cellophane band was wrapped around the portal vein just to constrict it. The dogs were closed and received proper postoperative care.
After two months the dogs were opened, liver wedged biopsies were taken and the pressure in the portal vein was measured. The dogs of the first group were closed after that, while in those of the second group the pressures in the splenic and left renal veins were measured and distal splenorenal shunts (DSRS) with spleno-pancreatic disconnection were performed. The dogs were closed and recieved meticulous postoperative care.