الفهرس Only 14 pages are availabe for public view
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Abstract
This thesis is constituted of three chapters:
Chapter I (Introduction)
Part I:
It deals with the importance of radioisotopes in medical applications, and the physical and biological properties of these isotopes. Also this part deals with the chemistry of iodine and methods of the production of radioiodine from tellurium targets specially dry distillation method and ion exchange method.
Part II:
It deals with general methods of labeling of organic compounds by radioiodine, especially the most important in nuclear medicine, their methods of production and applications.It also includs some techniques used for preparing of the radioiodinated compounds especially the electrophilic substitution technique. In this technique, oxidizing agents are used to oxidize iodide ions to iodonium ions that are capable to electrophilic attack on the alkyl group of the organic compound.
This chapter also deals with the receptor tracers, their types and the effects that can occur due to binding of these receptor tracers to cell membrane. Since these radiopharmaceuticals are used for diagnosis and therapeutic treatment of human diseases, also quality control tests such as determination of chemical purity, radionuclidic purity, radiochemical purity, sterility, and biodistribution are performed to ensure the purity, the safety and efficacy of these products for the intended nuclear medicine applications.
Chapter II (Experimental)
It contains information concerning chemicals, reagents, radionuclides, equipments and counting systems used in the study. It describes production technique of iodine-131 using ion exchange method and the electrophilic radioiodination using different oxidizing agents. Analysis of the products was performed using thin layer chromatography depending on the Rf values and the high pressure liquid chromatography (HPLC) using the reverse phase RP-18 column eluted with an appropriate solvent where each compound is identified by its retention time (Rt).