الفهرس | Only 14 pages are availabe for public view |
Abstract dipocytes are not merely inert storage depots for triglycrides but rather highly active cells with potent autocrine, paracrine functions sensing metabolic signals and secreting a large number of physiologically active polypeptides (Saltiel and Kahn, 2001). Adiponectin is the most abundant adipose specific protein and is exclusively secreted from adipose tissue (Maeda et al., 2001). Adiponectin stimulates fatty acids oxidation, reduces plasma triglycerides and improves glucose metabolism by increasing the insulin sensitivity. Adiponectin levels seems to be reduced in obese subject and prior to development of type 2 diabetes (Lindasy et al., 2003). The offsprings of mothers with diabetes mellitus are prone to adverse side effects such as macrosomia, which is strongly associated with fetal death, prematurity, birth trauma, and respiratory distress syndrome. Equally important, these offspring have a high risk of developing obesity, impaired glucose tolerance, and type 2 diabetes in adulthood (Weiss et al., 2000). Being closely related to insulin metabolism and lipid profile, adiponectin may play a role in regulation of fetal growth. Moreover, hypoadiponectinemia might be associated with the pathogenesis of macrosomia in infants of diabetic mothers (Lindasy et al., 2003). |