الفهرس 
Etiology of mitral valve regurgitationOnly 14 pages are availabe for public view
 |  | from | 144 |  |  |
| | | from | 144 | | |
Abstract
The major source of plasma BNP is cardiac ventricles, unlike ANP, whose major storage sites include both atria and ventricles. This suggests that the BNP may be a more sensitive and specific indicator of ventricular disorders than other natriuretic peptides. Unlike ANP, BNP has a minimal presence in storage granules. BNP release appears to be directly proportional to ventricular volume expansion and pressure overload .
BNP is an independent predictor of high LV end–diastolic pressure and is more useful than ANP or epinephrine for assessing mortality in patients with chronic congestive heart failure. BNP has been proposed as a tool to distinguish dyspnea of congestive heart failure from other causes of dyspnea.. It could become a useful test to screen for significant valve disease, LVH, atrial fibrillation, LV diastolic dysfunction as well as systolic dysfunction.