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Abstract
Our study was conducted on forty patients, asthmatic non-smoker as well as twenty healthy individuals served as a control group.
From the forty patients, twenty as well as the control group received active vitamin D3 0.5 g daily for one month. The remaining twenty patients received only their usual therapy. IL-10, IL-4, serum calcium and detection of asthma severity were done before and after the treatment in studied groups.
The results of this study showed;
•Significant rise was noticed in the number of severe cases after treatment among group B (patients didn’t receive active vitamin D3) in comparison to group A (patients received active vitamin D3) with P < 0.05.
•Significant decrease in severity score after treatment in group A in comparison to group B with P < 0.05•Significant increase in serum calcium after treatment in groups A, C versus group B with P < 0.05.
•Comparing bronchial asthma degree of severity, as severity increases, there is significant decrease in IL-10 and significant increase in IL-4 among group A.
•Highly significant increase in IL-10 after active vitamin D3 administration in group A in comparison to groups B, C with P < 0.01.