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Abstract This study was aimed at evaluate the adverse reaction of antituberculosis drugs on tuberculous patients under treatment and detect their effect on kidney function e.g uric acid and creatinine. The study included one hundred patients have pulmonary tuberculosis and thirty healthy control subjects. The patients were either admitted in the chest clinic or in chest Abbassia Hospital. Every sputum specimen was subjected to several bacteriological examination which were direct smear staining with Zeihl-Neelsen, digestion-decontamination procedure was done to every sputum specimen using petroff ‘s sodium hydroxide ( NaOH) method, then after processing, and culture on lowenstein-jensen media was done from the sediment that resulted after the digestion-decontamination method. All cultures were incubated at 37 °C up to eight weeks The numbers isolated strains of mycobacteria that were isolated from the 100 patients who have pulmonary tuberculosis were 76 strains (76%). the isolated strain were subjected to different biochemical reaction tests to identify the mycobacteia into species rate of growth , pigment production, niacin test, nitrate reduction, also, 76, strain were subjected to anti tuberculous susceptibility test by using proportion method with isoniazid,streptomycin, rifampin and ethambutol. Then the patients subjected to certain biochemical study including the measurment of plasma urate and U creatinine as both of the main kidneys function test. |