الفهرس 
Pharmacology of AntibioticsOnly 14 pages are availabe for public view
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Abstract
sir Alexander Fleming gave modern medicine a double-sedged sword by discovering antibiotics: an effective agent that would rapidly lose its effectiveness and create resistance when used inappropriately or extensively. Because antibiotics were very potent in killing bacteria both in vitro and in vivo, the temptation to administer them prophylactically is as old as their therapeutic use (Chang et al., 2003).
Although there are numerous studies in the past 50 years on the subject, a reduction in mortality has not yet been conclusively demonstrated. On the other hand, we are experiencing a dramatic increase in bacterial resistance worldwide and the inappropriate use of antibiotics is blamed as one of the most important contributing factors (Siegman et al., 2005).
Yet, antibiotics are still used prophylactically in many intensive care units (ICUs) today. The pro-and-con debate on this topic attempted to clarify and perhaps partially resolve this controversial issue by maximizing effect of antibiotics in bacterial eradication and minimizing their cost (Chang et al., 2003).