الفهرس Only 14 pages are availabe for public view
 |  | from | 167 |  |  |
| | | from | 167 | | |
Abstract
SUMMARY ASP COXCLUSfpN^ 121
SUMMARY AND CONCLUSIONS
Fibrosis is the most severe consequence of the liver injury thai occurs in most chronic Jiver diseases regardless of their aetiology. Recently hepatic fibrosis is now considered as a dynamic process involving synthesis and degradation of several proteins and macromolecules from the extracellular matrix.
Assessment of hepatic function and cell necrosis are well established by non invasive liver function tests. However, hepatic fibrosis can be estimated by liver biopsy which provides only static in contrast to dynamic information about hepatic fibrotic process. The ideal test should hr non invasive and easy to be done repeatedly.
Estimation of plasma laminin concentration considered non
invasive test to evaluate stage of hepatic fibrosis in chronic liver disease.
In this work sixty patients with chronic HCV were divided into 7 groups according to the stage fibrosis by hisiopathological examination
of liver biopsy.
The following liver function tests were performed for all patients: SGPT, SCOT SGPT/SGQT ratio GOT, alkaline phosphatase,
prothrombin concentration, AFP, serum albumin and serum bilirubin. Also portal vein diameter and plasma laminin were measured for all patients.
It was found that plasma laminin level was very significantly elevated on liver fibrosis and the level gradually increased with (he increase of stage of hepatic fibrosis.