الفهرس 
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Abstract
During the last d de beazotriazole-mediated syntheti methodolo has developed rapidly and I no become an import an thetic OQIfor many cnemi I processes, including multi P preparations 0 dl\l • biologi I active compound . and ’mhet)c analog of natural product Benzotri le has ’isted the ynthe i of a wide an e of useful orgarn compound du to the unique properties of’the benzctnazoly] ’roup 3 both a good nion-si bilizin tro Ip and good leaving group, i approach involves the rep of the preparancn of benzotriazole bilized intermedi tes, their trans ormations and final displacement of stabilizing group from nthcsized den tives, The prin ~p I steps in ell quenc re enerally the first and th on and a vari ty of benzorriazol a’ i ted tran orrnati 11 is some imes limited by the It il1\bdity of tile benzetriazcle dcrivati es and by th ility 0 the final intennediate to elimmate benzo riazolyl moietv, ovel n hetie metlUlds and a pro en . in benzorriazole ehernis could achi e the de ired diversification of chemical bjeet and method The main goal folic dissertation was the aboration 0 new synthetic appro hes to -substltu ed benzo nazol and their further applications ynthons in heterocyclic and organic chern’ try. hapt r I; ive a bri overview 0 benzotriazole chemistry, including common methodsto Db In the -sub tituted benzotriazoles and the COlMlOl types of their transformancn , apt r 2: This chapter highligh study of the nucleoph 6c Slit tlon of 0-- chlor lkyl benzomaaol with -necleophites uch n w transform tion: opened a direct and general lithe i rule fOT the ynlhcsis f benzotri oalkyltheiero romatic ii compounds 2. 9 ~k, 2.1211 b and 2.13. Our synth ic route allowed the synthcSl of previously known compounds 2.9a,b. in uperlor ’idd This methodol y required mild reaction condition that led 10 novel compound 1.9g~k derived r m aldeh ’des other than formaldehyde and benzotriazolyl kylheteroaromatic ystern 2.121,h nd 2.13 derived from add sensitive heterocycle h pter 3: highlights our tud)’ of’the ne transformations f ,N-dialkylamiooal )’1)- benrotrtazol 3.1 as eneralized iminium ion equivalent Thi~ new displacement of the Bt-moiety with phenol te anions opened a yruhetic route 10 previou I)’ unkn wn or mud to )’nthesize Mannich-typc produc nd, thu lowed exten ’on of the annich aminomtthyl tion of phenols to hete a hlli n nd benZ)’ ion. bsptcr 4. in lhi chapter we ha e introduced 11 novel altern live synthetic route or the synthesis 0 Q-benzotriazoly!-substituted teton 4.4 via oxidation of silyt enol ethers.4.2. uch a synrh tic approach been based n the oxidizing prop rty of 1-chlorobenzotriazole 4.J his methodology allowed the preparation of a variety 0 aromatic, aliphatic and aljc~lic etones 4.4 b nng a b nzotriazole moiety at the nrbon ilh view to extending lbe ynlhellc appli ions a benzotriazole derivatives. wc have examined he I yin bility ofbenzo nazolyl group In e-benzoniazol l-aron tic and alieychc ke ones \ e rbon components m P 2 11 pyridine ring nutation in traction with c Icon in I pr ce of amm niurn acet te nitrogen componem to tt in 2,4,6-triarylpyridlncs 4.9 1,2.• di rylindeno[l,2-blpyridines 4.9j k and 2,4.di ryt-S.6•dihydro-benzolhlquinolmes 4.91-1) Our merhodol proved to be ad ntageous alternative route becaus chi synlheti route provide upetio y-leldsand applicable POI only with phenac:etylden rive I al with (1- bstituted ketones in general hspter : p1 vide full e perimentaJ detail for our studi.