الفهرس 
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Abstract
The present study describes the preparation of the diazeniumdiolate derivatives of some pharmacologically-active compounds as NO Hybrids. In addition, some other diazeniumiolate derivatives were prepared to study the effect of the different substituents on the rate of diazeniumdiolate formation from their stayting secondary amines, and the rate of their dissociation NO. so, the diazeniumdiolates of the known antibacterial drugs, norfloxacin and ciprofloxacin were prepared and converted to their corresponding prodrugs. Also, the diazeniumdiolate hybrids of the anti-inflammatory drugs naproxene and flurbiprofen were prepared . The diazeniumdiolate of phenylpiperazine and its corresponding prodrugs were also prepared . For comparison with some previously prepared piperidine diazeniumdiolates, the diazeniumdiolates of piperidine 1-,2&3-carboxamides were prepared for studying the effect of different neighboring chemical groups on the rate of release of NO from these compounds. For the same purpose, the diazeniumdiolates of 3.5-dimethylpiperidine and the diazeniumdiolate of amino acid sarcosine and its sulphonated analogue were prepared. For studying the rate of diazeniumdiolate formation from the corresponding starting secondary amine, by using the exclusivelydesigned computerized NOtizer machine, containing (Prism program), different diazeniumdiolates were prepared.