الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 212 |  |  |
| | | from | 212 | | |
Abstract
- High fat feeding in male albino rats for long periods induces a moderate type 2 diabetic phenotype suitable for the study of type 2 diabetes and its cardiovascular complications. -Diabetes mellitus is a disease of major metabolic derangements and abundance of oxidative stress and other cardiovascular risk factors. - Treatments targeting oxidative stress, nitrative stress, and advanced glycosylation end products might help prevent, delay, or improve cardiovascular complications in diabetic patients. - Administration of B-blockers in animals fed a high fat diet did not worsen diabetic control, however, improvements were seen. - Carvedilol showed preferential effects on lipid profile, advanced glycosylation, and oxidative stress; factors that might induce cardiovascular disease. - Small dose of carvedilol (2 mg\kg\day) in the rat ( equivalent to adult daily dose of 25 mg) imparted cardioprotective effects on diabetic animals. - Previous reports in the literture on metabolic derangements induced by B-blockers although controversial might prohibit the use of a very important class of cardioprotective drugs in conditions like diabetes mellitus. - The selection of drugs for cardiovascular complication in diabetics should be based on well known benefits and associated risk.