الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
 |  | from | 218 |  |  |
| | | from | 218 | | |
Abstract
The aims of this study were to evaluate some currently used serological tests through comparison of VDRL; RPR; MHA-TPi and FTA-ABS results syphilitic patients and to study the influence of different socioeconomic factors on the occurrence of infection. 2 ) This study was carried out on a total of 300 individuals, consisting of 150 syphilitic patients from Khartoum, Khartoum North, Omdurman, Kosti and Niala Hospitals and from some private clinics. And control subjects, composed of 50 healthy individuals, 50 pregnant women and 50 malarial 3) Information was obtained from each syphilitic regarding personal data, social aspects, educational level, residence and migration. 4 ) A serum sample was obtained from each indi vidual for testing with VDRL, RPR, MHA-TP and FTA-ABS tests for detection of T. pallidum antibodies. 5 ) Comparison of the positive results of the four tests revealed that the FTA-ABS test was the Blast sensi ti ve in detecting syphilis infection (98) followed by MHA-TP (92), RPR(90) and VDRL (72). 6) FTA-ABS test was also highly specific (98.7) (97.3) (97.3),RPR (87.3) by and MHA-TP VDRL (80.7), in diagnosing the negative cases. 7) Good correlations obtained between the were four serological when each tests two tests were compared together. (67.33) 8 ) Although males were ’more affected (32.67), than females there no statistically was significant difference with sex. 9) The highest prevalence of syphilis infection was at the age group 21-30 years (46 ). 10) Syphilis infection was significantly higher travelled within Sudan (70.67 ). 11) infection The was highest of percentage (43.33) illiterate among cases who were and lowest among those who received uni versi ty studies (4.67 ) . infection was more 12) Syphilis prevalent among cases who were not working (24.67 ) and among labourers (19.33). 13) highest percentage of infection The found among the Jwamaa tribe (13.33). 13) highest percentage of infection The found among the Jwamaa tribe (13.33). from the above results it can be concluded that in syphilis infection is prevalent Sudan and should attention and consideration. - The results in this study indicate that there between and VDRL, RPR, MHA-TP FTA were agreement I ..J J . was ~s tests, however, the FTA-ABS was the most sensitive and specific test. - As evaluated here, it is difficult to judge that all the four serological techniques used in this study are ideal for diagnosis of syphilis infection. It should be borne in mind that, the reliable procedure of such a purpose should provide for a rapid, accurate and economical diagnosis infection. It is clear that the RPR test can be read a microscope and 1S intended to eliminate the need for daily antigen preparation and heating of serum before testing. These characters can facilitate the application of RPR test in field investigations and 1n the clinics where results are needed prompt 1 y . The MHA-TP test 1S simpler, more rapid and less expensive than the FTA-ABS test involved in this study. The performance of the test in microti tre plates, as shown in this study facilitates reading the reactions and substantially reduces the volumes ~ reagents required to perform the test. The FTA-ABS test has shown to be the most sensi ti ve and specific test used in this study. How ever, it demands, for reading, the use of an expensive equipment, a fluorescent microscope. 11 - The present findings levels factors such as migration, been clearly have of syphilis. also showed that some linked occupation and educational to the prevalence.