الفهرس 
Normal cardiac electrophysiology
MATERIAL AND METHODSOnly 14 pages are availabe for public view
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Abstract
Peri operative arrhythmia is the most important sign to be diagnosed and treated. The arrhythmia caused by adrenergic drugs (e.g. epinephrine or norepinephrine) during anesthesia with volatile agents is one of the most important arrhythmia. The dysrhythmogenic effects of epinephrine on the heart during halothane anesthesia involve action mediated by a.I-and B adrenoceptors. There is now a wide range of antiarrhythmic drugs available for the treatment of arrhythmia. The chosen drug should be safe and effective as many drugs have significant side effects and can themselves precipitate arrhythmia. Calcium channel blockers e.g. Verapamil, P- blockers e.g. esmolol which is a selective blocker and amiodarone (which has sodium and calcium channel blockade and adrenrgic antagonism effects) were previously used for the management of halothane-epinephrine induced arrhythmias. Recently, adenosine a rapidly acting endogenous purine nucleoside with ultrashort duration of action was approved for the management of arrhythmias. The present study was designed to compare the effect of the four drugs decribed above in the treatment and prevention of halothane-epinephrine induced arrhythmias in dogs. The present experimental” study was performed on forty-eight dogs. Anesthesia was induced using thiopentone sodium, trachea was intubated and anesthesia was maintained using semiclosed circuit mixture of 1.5% halothane in 100°,10 Oxygen. The forty-eight dogs survived and continued the experiments. Anesthesia” was maintained for thirty minutes to achieve a steady state. After stabilization of anesthesia baseline data were collected and limb lead II of ECG were recorded.