الفهرس 
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Abstract
Hae:nodialysis (HD) patients are at increased risk of acquiring larenteralLy-transmitted hepatitis viruses, from blood transfusion or os(\Comi.:1 transmission in the dialysis units. HBV was the major use of parenterally-transmitted viral hepatitis is those patients. The iscovery of HCV had shed light on the cause of NANBH in The high risk of acquiring hepatitis viruses in is likely to extend to the newly discovered, renteraEy-transmitted Hepatitis G virus (HGV). Hepltitis G virus is a single-stranded, positive sense RNA virus, longing to the family Flaviviredae. It posseses a genome of about ’300 nudJeotides, that encodes a single large polyprotein of about Seqllences consistent with structural proteins are located at the !i?f]niIUs (5’end) and non structural proteins at the C-terminus teEd). EGV contains many protein motifs including two envelope oltms E I-E2), P2 ,like protein, zin protease, serine protease, h,ase Dd RNA dependent RNA polymerase. The non structural O1:ms iidude NS2, NS3, NS4b, NS5a and NS5b. The virus has been classified into five genotypes (Type I to type V), type II and IH are divided into two subtypes each, a and b. There i~ a high sequence conservation between different HGV isolates from the overall conservation is about 90at the Sequence analysis showed that HGV is closely related to other mavi-like viruses, associated with hepatitis in human and animals, fuc!uding GBV-A, HCV and GBV-B.