الفهرس 
LEUKEMIAOnly 14 pages are availabe for public view
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Abstract
Drug resistance is one of the most significant challenges facing clinicians who treat malignancies. Despite major advances in cancer chemotherapy,many patients develop recurrent diseases after initially responding well to, therapies.Over the last 20 years, experimental models and clinical research have identified several causes of multidrug resistance (MDR) in tumors. This improved understanding of the mechanisms involved in multidrug resistances has permitted the development of new therapeutic strategies.A representative cause of drug resistance is the expression of MDR 1 gene and its product, P-glycoprotein, on the cell surface membrane.P-glycoprotein acts as an efflux pump excreting chemotherapeutic agent from the cells before they can exert their cytotoxic effects.P-glycoprotein contributes to chemotherapy failure in acute leukemia.However, the exact prognostic significance of this resistance mechanism is still unclear, mostly due to problems in-.the methods of P-gp detection, it’s function and other resistance related proteins.