الفهرس 
The heartOnly 14 pages are availabe for public view
 |  | from | 148 |  |  |
| | | from | 148 | | |
Abstract
Adriamycin is an anthracycline anti-neoplastic drug used in the treatment of a variety of human neoplasma. However, its toxicity on different organs especially the heart compromises its clinical effectiveness and is a major limiting factor for its clinical use in cancer chemotherapy (Saad et al., 2000). The current study was designed to investigate the histological and histochemical changes that can be inducaed by ADR on the heart, liver and kidneys of the adult male albino rats using light microscopy and evaluate the presumed protective effect of captopril against ADR toxicity as well as the possible role of dose fractionation on reducing ADR- toxicity. Thirty six adult male albino rats were used in the present study. They were classified into 6 groups. Every group comprised 6 rats, 2 of them were used as control rats, and the remaining 4 were used as experimental rats. Group (1) received a single dose of ADR, 15 mg/kg while group (3) and group (5) received 3 mg/kg of ADR weekly for 2 and 5 weeks respectively. Groups (2),(4), and (6) received the same dose of ADR as in group (1),(3), and (5) respectively in addition to daily captopril, 10 mg/kg. Each group was sacrified at the exact; their organs were immediately extracted, washed by normal saline and fixed in 10% formal saline. Sections were prepared for staining with Hematoxylin & Eosin, Massons’s trichrome and Periodic acid Schiff’s srains. The stained sections were examined under the light microscopy to demonstrate the general histological structure, the connective tissue element, and the PAS+ve materials.