الفهرس 
Acute leukaemiaOnly 14 pages are availabe for public view
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Abstract
Acute myeloid leukaemia is a group of marrow based neoplasms. It has clinical simultaneous but distinct morphologic, imrnunophenotyping and cytogenetic features. They are considered as malignancies of immature hemopoietic cells and characterized by accumulation of blast cells in the bone marrow, peripheral blood, and other tissues, with suppression of the hematopoietic function. Cytogenetic abnormalities in leukemia can be characterized as changes that involve chromosome number and structure.Glutathione S-transferases (GSTs) are a multigene family of cytosolic isoenzymes contributing to the detoxification of activated carcinogens, whether exogenous or endogenous reactive species, several environmental mutagens and anticancer drugs.GST is one of the most important phase I1 bio-transformation reactions of reduced glutathione and represents a great family of ubiquitous cytosolic or membrane-bound enzymes, which display distinct catalytic properties and play separate roles in the bio-transformation and detoxification process.