الفهرس 
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Abstract
SUMKARY AND COHCLUSXONS
This study was carried on 30 patients attending the
out-patient clinic of the Rheumatology and Rehabilitation
Department of Benha University Hospitals. They were
classified into two groups :
Group A :
Consisted of 15 patients with rheumatoid arthritis
diagnosed according to the American Rheumatism Association
criteria. All the patients presented with knee effusion. ,
’They were 10 females (66.7%) and 5 males (33.3%), their
ages ranged between 32 and 60 years, with a mean of 43.4 ±
3.55 years.
Group B :
Consisted of 15 patients with osteoarthritis of the
knee diagnosed according to the clinical features and
supported by typical radiological changes. All the
patients had synovial effusion. They were 8 females
(53.3%) and 7 males (46.7%), their ages ranged between 41
and 61 years, with a mean of 52.06 ± 2.79 years.
* All the patients were subjected to full history taking
and complete clinical examination.
* Blood and synovial fluid samples for every patient were
obtained in the same day for determination of
- E.S.R.
- Complete blood picture
•
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- Rh. factor.
’- Plasma and synovial fluid, fibronectin concentrations
using radial immunodiffusion technique.
The results of the laboratory investigation of our
patients were as follow
*. The mean concentration of fibronectin in, the synovial
fluid of R.A. patients was (39.9±3.l7 mg/dl) and showed
a highly significant elevation (P <0.001) when compared
••
to the mean plasma fibronectin concentration of the same
patients which was (26.5 ±2.75 mg/dl).
* The mean concentration of fibronectin in the synovial
fluid of O.A. patients was (30.73±3.08 mg/dl) and showed
a significant elevation (P <0.05) when compared to the
mean plasma fibronectin concentration of the same
patients which was (25.4 ±2.39 mg/dl).
* The mean concentration of fibronectin in the plasma of
R.A. patients showed insignificant differences (P >0.05)
when compared to the mean concentration of fibronectin
in the plasma of patients with O.A.
* The mean concentration of fibronectin in the synovial
fluid of R.A. patients showed a highly significant
elevation (P <0.001) when compared to the mean
concentration of fibronectin in the synovial fluid of
patients with O.A.
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•
* The plasma and the
in R.A.
>0.05)
synovial
patients
with any
fluid fibronectin
concentrations
correlation. (P
showed
of the
insignificant
clinical or
laboratory parameters.
* The plasma fibronectin concentrations in R.A. showed a
highly significant correlation (r = 0.9) (P <0.001) with
the age of the patients.
* The plasma
concentrations
correlation (P
and the synovial fluid
in O.A. patients showed
>0.05) with any of the
fibronectin
insignificant
clinical or
laboratory parameters.
- from these results we concluded that :
* In rheumatoid arthritis and osteoarthritis there is
elevation of fibronectin concentration in the synovial
fluid above the plasma level.
* Also, because the concentrations of either plasma or
synovial fluid fibronectin in R.A. were insignificantly
correlated with the inflammatory indices, so they can
not be used as indicators of disease activity.