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Abstract 156 SUMMARY This study included 41 patients who presented with chest pain and scheduled to have cardiac catheterization and coronary angiography for suspected coronary artery disease, their ages ranged between 38-68 years with an average of 52.6 years. There were 23 males and 13 females. 24 patients were smoker, 27 patients were hypertensive, 15 patients were diabetic, 25 patients had a history of high cholesterol level, and 17 patients had a history of previous myocardial infarction. 17 patients had a pathological Q wave of the myocardial infarction in the resting twelve lead electrocardiogram, and 14 patients had increased cardiothoracic ratio by postero- anterior chest x-ray film. 26 patients had resting wall motion abnormalities by transthoracic echocardiography, the mean resting wall motion score index was 1.26 and the mean ejection fraction was 56.4%. 29 patients had left ventricular diastolic dysfunction. 25 patients had a positive exercise ECG testing, 13 patients had a negative test, and 3 patients had an inconclusive test. 30 patients had a positive stress transesophageal echocardiography and 11 patients had a negative test with a mean maximum of paced heart rate was 143.7 beats/minute. The mean resting wall motion score index was 1.36 and the mean wall motion score index at the maximum paced heart rate was 1.57 with significant difference (P value < 0.05). 157 10 patients (Group I) had a normal coronary angiography and 31 patients (Group II) had diseased coronary arteries. 10 patients (Group A) had single coronary artery disease, 9 patients (Group B) had double coronary artery disease, and 12 patients (Group C) had triple coronary artery disease with the mean ejection fraction was 53.4%. There were significant differences between Grol(JlI and U in the following Age, maximum achieved heart rate during exercise ECG testing, maximum paced heart rate and chest pain during stress TEE. (P value < 0.05). There were highly signifiCant differenceS between Grol(JlI and U in the following dJlm; Sex, smoking, history of high lipid level, history of previous myocardial infarction, transthoracic echocardiographic ejection fraction, resting wall motion score index, left ventricular diastolic dysfunction ,chest pain during exercise ECG testing, resting transesophageal wall motion score index, stress transesophageal wall motion score index and ejection fraction by cardiac catheterization. (p value < 0.01 ) There were sjgnificant differenceS between group A. B. and C jn the following data: Transthoracic echocardiographic ejection fraction, resting wall motion score index, maximum paced heart rate, resting transesophageal wall motion score index, stress transesophageal wall motion score index and ejection fraction’ by cardiac catheterization. (P value < 0.05). 158 Exercise ECG testing had a 79 % sensitivity, 78 % specificity and 75 % positive predictive value. Stress transesophageal echocardiography had a 96% sensitivity, 100% specificityand 96% positive predictive value. There were significant differences between exercise ECG testing and stress transesophageal echocardiography in sensitivity, specificity and predictive value The sensitivity of exercise ECG testing for group A, Band C were respectively 50%, 88% and 92%. and for stress transesophageal echocardiography were respectively 100%, 88% and 100%. In conclusion,the use of simultaneous transesophageal echocardiography and transesophageal atrial pacing in detection and evaluation of coronary heart disease is a feasible, safe, promising new echocardiographic stress technique and can be recommended for evaluation of patients with physical handicap or poor exercise tolerance with inadequate transthoracic echocardiographic imaging . - ----- |