الفهرس 
Material and methodsOnly 14 pages are availabe for public view
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Abstract
This study comprised 4 groups, each of them included
10 subjects, the first group diabetic patients, the second
group ischaemicpatients, t~e third group diabetic ischamic
patients and the fourth group normal control subjects. All ..
were selected from Benha University Hospital, out patients
’clinic of medicine. To all group the following investigations
were done :_
Urine analysis, fasting and post-prandial blood sugar, u.tc
acid, fundus examination, electro cardiography and amino
acid profile.
The diabetic patients showed significant decrease
in plasma level of alanine, glycine, proline, arginine, tyrosine
histidine, lysine and threonine amino acids, while plasma
level of aspartic, serine, cystine, glutamic, valine, leucine
and isoleucine amino acids showed significant rise in diabetic
patients.
Also the ischaemic patients showed significant decline
of plasms level of the most amino acids except serine which
showed significant rise •
.
Also the diabetic ischaemic patients showed significant
rise of plasma level of aspartic, serine, glutamic,cystine
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valine, leucine and t so le uc i ne amino acids.
Serum uric acid showed non-significant changes in
diabetic, ischaemic and diabetic ischaemic patients in
comparison to normal control subjects.
we conclude and recommend that :-
(1) Plasma amino acids profile is useful in identifying
changes in amino acid metabolism.
(2) The metabolism of amino acids is closely related
to c~rbohydrate metabolism.
(3) The effect of diabets mellitus with its alteration
in insulin and glucagon secretion on the metaboli c
response to protein meal has been considered.
(4) The amino acid profile in diabetic patients
is as follows :-
a) Significant rise of branched chain amino acids
(valine, leucine and isoleucine) in diabetes,
this may be explained by the fact that the oxidation
of these amino acids by muscle tissue is augmented,
while their output fnm muscle and liver is unchanged.-