الفهرس 
Free radicalsOnly 14 pages are availabe for public view
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Abstract
It is emphasized that oxidative damage could be a consequence of tissue injur or as a cause of it ( Halliwell, 1994 ).The generation of reactive free radicals reduce the antioxidant defenses in the liver through stimulation of lipid peroxidation which has been implicated in a wide variety of hepatic injuries and diseases ( Ross & Moldeus,l991 ).A great deal of interest focuses on the mechanisms whereby the antioxidant agents can prevent or decrease the potentially harmful radical reactions ( Sies &Krinsky, 1995 ).Vitamin E ( Reynolds,l996 b* ) , vitamin A ( Cahill et a1.,1993 ) , and silymarin ( Flora et a1.,1998 ) are considered to have antioxidant activity , thus may play a valuable role in cellular defense in the liver.Hopefully , this realization will contribute to the development of new preventive and therapeutic strategies of liver disorders ( Halliwell, 1994 ).A particular area of interest in pharmacology is the possibility that the side(- effects of several drugs involve increased oxidative damage ( Aust et a1.,1993 ).Drug-induced hepatotoxicity , e.g. acetaminophen , is shown to increase lipidperoxidation ( Reiter & Wendel, 1983 ).Also , hepatic schistosomiasis causes damage and fibrosis of the liver by an oxidative mechanisms ( Pincus et al., 198 1 and Bissell et al., 1990 ). The aim of this work is to evaluate the role of vitamin E , vitamin A , and silymarin (as antioxidants) on prognosis of acetaminophen-induced hepatotoxicity and experimentally-induced hepatic fibrosis by schistosoma mansoni infection in mice.The study evaluates their effects on hepatic lipid peroxides level , liver function tests ( including SGPT; SGOT; prothrombin time & activity; total bilirubin; and albumin level ) , and lastly the histopathological changes occurring in the liver of mice.