الفهرس 
Convulsive sundromeOnly 14 pages are availabe for public view
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Abstract
Benzodiazepines are coinmonly used for different pharmacological action (Bertram G. Kafzung, 1989). For the past 20 years, they have been the most colmnonly prescribed psycl~otsopicd rugs (Burrows G. et a/., 1984). They are also used as sedatives and for induction of anesthesia or sedation in surgical procedures (Cohn J. et a/., 1989). Some benzodiazepines induce skeletal muscle I~ypotonia and relaxation, e.g. diazepam which can control status epileptics (Muttson RH ef a/., 1985),-but it may be followed by long acting anticonvulsants as phenytion (Hollister, 1985). Diazepam also relieves muscle spasm and spasticity (Atkinson et a/., 1987). As a result of the individual variability in response and the dosage needed, was the discovery of the first specific benzodi azepi~ie antagonist, fluinazenil (Haefely, 1983). This discovery was a peat success for the physicians and in order to normalize the patients. This antagonist facilitates the co~ltrolo f the duratio~la nd the inte~lsityo f action of the bezodiazepines. The aim of this work is to study the changes of serotonin and prostaglandins in the brain of the rats after experimental conv~ilsion using pentylenetetrazol then studying such changes after control of convulsio~~uss ing benzodiazepine coinpo~ulds, then studying the effect of flumazenil on these changes. This work is carried out on 1 10 rats were classified into 1 I equal groups: First group: Control groups. Second group: Received diazepam. Third group: Received midazolam. Forth group: Received flumazenil. A Fifth gro u 1): Received pentylenetetrazol. Sixth groups: Received diazepam and pentylenetetrazol. Seventh group: Received midazolam and pentylenetetrazol. Eight groups: Received flumazenil and diazepam. Ninth group: Received fluinazenil and inidazolain. Tenth group: Received flumazenil, diazepam and pentylenetetrazol. Eleventh group: Received flunlazenil, midazolani and pentylenetetrazol.