الفهرس 
Organization of eukaryotic cellsOnly 14 pages are availabe for public view
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Abstract
Cadmium is a highly toxic metal ion and is regarded as one of the most important environmental pollutants. It is released into the environment essentially by human activities and finds its way into the soil, air and water. Moreover, the extensive usage of cadmium in industrial processes has resulted in occupational exposure to a variety of individuals. This study was performed to detect the degree of genetic abnormalities induced by cadmium and the possible role of vitamin C as a protective agent against cadmium genotoxicity. Materials and methods : This work included both in vivo and in vitro studies. I- In vivo studies : In the present work, 144 adult male albino mice were used. They were classified into two main groups : 1 - group A (included 64 mice) : which was used for the study of bone marrow chromosomal aberrations and mitotic index. It was divided into two groups : A1 (for the study of the effect of CdCl2 alone) and A2 (for the effect of CdCl2 together with vitamin C). Each of them included 32 mice which were divided into : - The control animals (12 mice) were injected I.P. with distilled water daily for the same four periods as the corresponding experimental animals (3 control animals for each period). Summary and Cunchion 174 - The experimental animals (20 mice) of group A1 were injected I.P. with CdC12 alone (0.25 mg/kg body weight) while those of group A2 were injected with both CdC12 (in the same dose) and vitamin C (10 mg/kg body weight) daily for different periods(one, two, three and four weeks; 5 animals for each subgroup). At the appropriate date, all animals were sacrificed 24 hours after the last injection. The femurs of each animal were dissected out and the bone marrow cells were collected and fixed, then dropped on clean slides which were stained with Giemsa stain. 2- group B [included 80 mice) : which was used for the study of sperm head abnormalities. It was divided into two groups; B1 (for the study of the effect of CdC12 alone) and B2 (for the effect of CdC12 together with vitamin C). Each of them included 40 mice which were divided into : - The control animals (15 mice) were injected I.P. with distilled water daily for 5 consecutive days. Then, the animals were sacrificed after the same intervals as the corresponding experimental animals (3 control animals for each period). - The experimental animals (25 mice) of group B1 were injected I.P. with CdC12 alone while those of group B2 were injected I.P. with both CdCl2 and vitamin C (in the above mentioned doses) daily for 5 consecutive days. Then, the animals were sacrificed after different intervals which were one, two, three, four and five weeks from the last injection (5 animals for each period). The epididymes of each animal were dissected out and the Summary and Cowhion 175 sperms were collected. Smears were prepared and stained with Eosin.