الفهرس 
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Abstract
Thanks to our merciful GOD for the plentiful blessings and thanks to GOD once more for enabling me to prepare this thesis.
I wish to express my deepest appreciation and gratitude to Prof. Samir Sayed Abd El-Kader, Professor and head of Cardiology, Faculty of Medicine, Assiut University for his effort, activities and experience for the development and supervision of this work. I also wish to express my respectful indebtedness for his valuable advice as well as his tolerance and patience in revising the thesis.
I would like to express my gratitude to Prof. Thorya Said El-Deeb, Professor of biochemistry, Faculty of Medicine, Assiut University for her valuable help and indispensable suggestions during planning and carrying out this work and I am absolutely lucky to be supervised and directed by her.
With considerable appreciation, I express my great indebtedness to Dr. Nagla T. El-Melegy, Lecturer of Biochemistry, Faculty of Medicine, Assiut University, for her authentic guidance and magnificent assistance and Kindly offered her remarkable experience through revising every part of this thesis.
I am also indebted to Prof. Hosny A. Hassan, Professor and head of Biochemistry Department, Faculty of Medicine, Assiut University, for his valuable support during the conduction of this work.
I am also so grateful for Dr. Alaa Shalaby, for his patience in the statistical part.
I am also so grateful to Dr. Amr Youssef, Lecturer of Cardiology, Faculty of Medicine, Assiut University, for his patience in the clinical part and collection of samples.
Special thanks are own to all my Professors and Staff members of Biochemistry Department , Faculty of Medicine, Assiut University for their continuous encouragement and support.
Sahar El-Deek Mohamed
2003