الفهرس | Only 14 pages are availabe for public view |
Abstract The aim of this work was to study the level of total cholesterol, HDLc, LDLc, total phosphalipids, triglycerides, fasting and post-prandial insulin levels in the serum of bilharzial hepatic fibrosis patients with and without ascites, in a trial to correlate between these changes and the clinical condition of these patients. The study was performed on the following groups : 1- Pathological group : Thirty patients with bilharzial hepatic fibrosis. - Group I: Fifteen cases without ascites. - Group II: Fifteen cases with ascites. 2- Control group : Ten normal control subjects for comparison. The patients were selected according to careful history, clinical examination, liver function tests, ultra-sonography, rectal snip and finally confirmed by liver biQPsy. All the selected patients and control subjects were subj ected to the following investigation’ : Total serum cholesterol, HDLc, LDLc, total phosphalipids, triglycerides. fasting and post-prandial glucose and insulin serum level. The results obtained revealed that : Total cholesterol, HDLc, LDLc, total phospholipids and triglycerides levels were found to be lower than that of normal control subjects and this decrease was statistically significant. The cholesterol 1 phosphalipids ratio was lower than that of normal control but this decrease was statistically insignificant. These results explain and confirm the low incidence of atherosclerosis, hypertension and myocardial infarction in patients with bilharzial hepatic fibrosis. The fasting gI.ucoselevel was found to be within the range of normal control in both groups of patients while the post-prandial level showed statistically significant elevation in both groups but more in ascitic cases. The fasting and post prandial insulin level showed statistical significant elevation in both groups of patients compared to the normal control group and more in ascitic group than the non-ascitic one. This high level of insulin in serum of patients with bilharzial hepatic fibrosis would not only explained by the impaired trapping and degradation by the impaired hepatic cells but also there would be insulin resistance which explain the presence of post-prandial hyperglycaemia inspite of this high level of insulin, also this explain the glucose intolerance in bilharzial hepatic fibrosis patients. |