الفهرس | Only 14 pages are availabe for public view |
Abstract Aldicard (2-methy 1.2 (methylthio) propionaldfehyde-O-(methylcarbamoy1) oxime) is the most potent commercially available carbamate posticde asnd is an unusal source of acute humam poisonings. There is 110 systemic investigation of this compound as regards its interaction with the forins of AChE (soluble and membrane-bound) and the types of inonoainine oxidase (A and B) in whole and different parts of rat brain neither in vivo nor in vitro. These two enzymes under study are responsible for the metabolism of two important ne~~rotransmitters (ACh and 5-HT). The present study was an attempt to determine the inhibitory power of aldicarb on ACE forins (S and MB) represented in its biinolecular rate constant, the carbainylation rate and the type of inhibition. It also determines the inhibitory power of aldicarb on the types of MA0 representing its affinity to the substrate-binding site and the type of inhibition. |