الفهرس 
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Abstract
It was reported that heterocyclic nucleus likes thiazoles, oxazoles,
:riazoles, pyrazoles, pyridazines, phthalazine, oxapyrazoles and oxadi
azines were exhibits biological activities [209.212] and some of which have
surface active properties. This encourage us to prepare some heterocyclic
compounds having the above nucleus and using commercial fatty acids
~:oleic, lauric and caproic acids) as starting material to synthesis
compounds having a double function as antimicrobial and surface active
agents.
- Part(1)
Long chain fatty acid (oleic, lauric and caproic acids) hydrazides
(2a-c) were prepared by the reaction of their acid chlorides with
hydrazine hydrate in dry acetone. Reactions of fatty acid hydrazides (2ac)
with carbon disulphide affords 5-alkyl-2-thione-l, 3,4-oxadiazole (3ac).
Treatment of the acid hydrazide (2a-c) treated with chloroacetic acid
afforded 2-alkyl-l,3,4-oxadazine-6-one (4a-c). Reaction of the same
hydrazides (2a-c) with phthalic anhydride gave 1 -N-alkanoylphthalazine
3,8-dione (5a-c). The reaction of fatty acid hydrazide (2a-c) with phenyl
isothiocyanate yielded thiosemicarbazide derivatives (6a-c) as key
intermediates.Triazole (7a-c), oxadiazole (8a-c) and thiadiazole (9a-c)
derivatives were produced via the reaction of fatty acid hydrazide with
phenyl isothiocyanate followed by treatment with NaOH, 12/1<1 and
H3P04 respectively. The reaction of fatty acid hydrazide (2a-c) with
benzaldehyde gave Schiff base derivatives (1%-c). Finally, Thiazole
derivatives (ha-c) were prepared from the reaction of thioglycollic acid
with the adduct of the schiff base (lOa-c).