الفهرس 
SummaryOnly 14 pages are availabe for public view
 |  | from | 131 |  |  |
| | | from | 131 | | |
Abstract
!he pressent work deals w:l. th synthesis and. reactions of 4-(p-tolyl)-5,6,7,8-tetrabromo l{2H) phthalazinone with
some eleotrophiles e.g. ethyl bromoacetate and. methyliodide;
and some nuoleophiles e.g._ carbon nucleophiles (Grigne.rd reagents), and oblorine nuolophiles (POC13/PC15). The
phthalazinone derivative reacts with ethyl bromoacetate in
dry acetone and anhydrous potassitllll carbonate as a catalyst and giTes 1-0-carboetboxymetbylphthalazine derivative as
a sole product~ On the other hand, when the reaction was
carried out in the presence of pyridiM as a catalyst
2-etbo:rycarbo~lmetbyl derivative was obtained as a sole
product (i.e N-alkyl derivative and no 0-alkyl derivative
was obtained). Similarly, metbyliodide reacted with the
phthalaziDo!’le derivative by using pyridine as catalyst and.
gave Z•llletbyl-4-p-(tolyl):..5,6,7,B-tetrabromophthaJJaz!l..ne.
The latter compound having methyl group activated by
heteroaromatio moiety, and its reactivity was tested b,y
condensation with aromatic aldehydes and phthalimide. Also
in this work the author planed to investigate the reactivity
ot the titled phthe.lazinone which contains two reaction
site’s for reaction with alkyl or aralkyl magnesium halide
under Gr:l.gnard reaction conditions ( C=O and -C=N), the
results cited there in the texet.
This. wark also deals with preparation ot the
cblorophthslazine via the interaction ot tbe titled
phthalazinone with P0013/P015 mixture, the cbloroderivative
having chlorine atom activated b1 heterrl moietr,
therefore~ nucleophilic substition reaction b.1 nitrogen
nucleophiles took place readil1 with the cbl~ro substrate.
Structure ot all s1nthesised compounds had been
elucidated via chemical ’tools and ph1sical tools e.g. IR
spectra and 1R-NMR spectra.