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Abstract Summary and Recommendations The results of the study showed the following: 1. 69.4% of patients were 50 years old or more. There IS an increase in the incidence of LRTI with increase of age. 2. The incidence of COPD in males is higher than in females (86.7% compared to 13.3%). Also the incidence of pneumonia in females is higher than in males (53.3% compared to 46.7%) . 3. The most prevalent organisms isolated from patients with pneumonia were Pseudomonas aeruginosa: 19 (31.7%) cases, followed by Klebsiella pneumoniae: 17 (28.3%) cases. While the most prevalent isolate from patients with COPD was Streptococcus pneumonia:4 (26.6%) cases 4. Among Gram positive cocci, Streptococcus pneumoniae was detected in 3 cases (5%) of pneumonia cases, as well as 4 cases (26.6%) COPD cases. MRSA also was isolated from 11 cases (18.3%) of pneumonia but non of patients diagnosed as COPD showed any isolates ofMRSA. 5. Among Enterobacteriacae group, the most predominant isolate was Klebsiellapneumoniae 17 (28.3%) cases of pneumonia, while Klebsiella pneumoniae was not isolated in any patient with COPD. Pseudomonas aeruginosa show higher occurrence in cases diagnosed as pneumonia: 19 (31.7%) cases on comparison with the frequency of them among COPD patients: 3 (20%)cases 6. Legionella pneumophilla was diagnosed by indirect immunofluorescence(IgM) test in 4 (6.7%) patients of pneumonia and Mycoplasma pneumoniae was diagnosed in 5 (8.3%) cases. Both were not -114 - Summary and Recommendations detected in GOPD. Chlamydiapneumoniae was detected in 3 (5%) cases of pneumonia and one case (6.7%) of COPD. 7. The most prevalent organisms isolated in HAP were Pseudomonas aeruginosa 17 cases (37.8%), followed by Klebsiella pneumoniae 15 (33.3%) cases. While in CAP patients the commonest isolates were Streptococcus pneumoniae: 3 cases (20%) followed by Pseudomonas aeruginosa: 2 cases (13.3%). 8- Out of75 ’cases ofLRTI ; 44 cases (58.7%) had monomicrobial and 25 cases (33.3%) had polymicrobial infection while 6 cases (8%) could not be diagnosed neither by culture nor indirect IMF test 9. Out of 60 pneumonia cases 42 (70%) were mechanically ventilated and 18 (30%) cases were not in need for mechanical ventilation. While out of the IS cases of COPD 13 (86.7%) cases were mechanically ventilated and 2 (13.3%) cases were not mechanically ventilated. 10. Out of 45 HAP patients 30 (66.7%) were mechanically ventilated and IS (33.3%) were not mechanically ventilated. While Out of IS CAP patients 12 (80%) were mechanically ventilated and 3 (20%) cases were not in need to mechanical ventilation. II. Eleven MRSA were isolated, 6 of which were isolated from patients with CNS disease (75%) followed by 2 isolate from patients with chest disease (18.2%) -115 - Summary and Recommendations 12. (47%) of isolated Klebsiella pneumoniae, (8 out of 17) were trom patients with cardiac disease. Followed by 3 isolates from patients with chest disease (17.6%). 12. (31.8%) of isolated Pseudomonas aeruginosa (7 out of 22) were equally isolated from patients with CNS disease and diabetes followed also by equal isolates from patients with chest and cardiac disease 5(22.7%) cases. 13. Out of 60 patients with pneumonia admitted to ICU 28 (46.7%) were improved either discharged or refered to other department in the hospital and 32 (53.3%) were died. This difference is statistically insignificant. Out of IS patients of COPD 13 (86.7) were improved and 2 (13.3%) were died. 14. Gram positive COCCI and enterobacteriacae were sensitivite to Imipenems 100% followed by Amikain. While thev were resistance to Penicillin, Clarithromycin, Oxacillin and Metronidazole. |