الفهرس 
Material and methodsOnly 14 pages are availabe for public view
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Abstract
Many studies suggested that magnesium does reduce mortality in
high risk patients including the elderly and/or those not suitable for
thrombolysis, (Scliecliter et ai; 1996).
This work is designed to clarify the effect of magnesium infusion on
patients with acute anterior myocardial infarction who received
thrombolytic therapy.
Thirty five patients were randomized into two groups. Magnesium
group received 8 mmol magnesium sulfate as a loading dose then 65 mmol
infused over 24 hours. All patients received the usual treatment of
infarction.
The results of this work were:
The heart rate was not changed but the blood pressure fell 5-10
mmHg, heart block, heart failure did not occur in both groups. Flushing
and occasional nausea and local discomfort occurred in two patients of the
magnesium group.
* CPK was elevated in the control gorup and reached a significant
level in the second day while SGOT & LDH did not differ between
the two groups.
* Echocardiographic results showed that, wall motion and E.F were
better in the magnesium group. Ejection fraction was higher in the
magnesium group (statistically signficant) but the I fractional
shortening and E/A. ratio showed no difference between the two
groups.
* The duration of exercise test was longer in magnesium group. ST.T
changes occurred more frequently in the control group. The
difference between the two groups was statistically significant.
Eighty seven percent of patients in the magnesium group achieved
their target heart rate while only seventy five percent of patients in
the control gorup reached it.
* No mortality was detected in both groups.
Given the current escalating costs of health care delivery for acute
myocardial infarction patients and the notable absence of any other
promising drug regimens for protection against reperfusion injury, it seems
unwise for clinicians to prematurely cast aside an inexpensive drug that
can be adminstered anywhere along the route between the patient’s home
and the coronary care unit.