الفهرس 
Material and methodsOnly 14 pages are availabe for public view
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Abstract
This work aims studying of some immunological features of women
suffering from unexplained spontaneous abo rtions, These studies include
1) prevalence of HLA-B12 and -B17 among cases with sharing with their
spouses. 2) prevalence of C.M.V. IgG and IgM antibodies and their
immune response to C.M.V. 3) prevalence of ANA positive test results
4) Determination of serum total IgM.
Ninety two couples with repeated spontaneous abortions and fifty
control couples were included in this study.
Study group was divided into different subgroups according to type of
abortion, frequency of abortion and age subgroups.
Both groups also were divided into further subgroups in case of
C.M.V. according to residence and socioeconomic levels.
It is concluded that HLA-B12 and -B17 were nearly similar prevalent
in both study and control groups. Also sharing of these antigens between
partners was nearly similar between both groups. Prevalence of positive
results of C.M.V. IgG antibodies were significantly lower in study group
than control group. Also positive results of ANA were significantly higher
in study group than control group. Total serum IgM gammopathy was
non significantly higher in study group than in control group.
Secondary aborters were more positive for HLA-B12 and sharing
than primary aborters. Also they were more positive for HLA-B17.
Primary aborters were more significantly seropositive for C.M.V.
IgG antibodies, but less as regard to C.M.V. IgM antibodies than
secondary aborters. Primary aborters were more positive for ANA, but
less as regard to IgM gammopathy than secondary aborters.
Women who aborted less than five times were more positive for HLAB12
and HLA-B17 than women who aborted more than five times. Also
they were more seropositive for C.M.V. IgG antibodies but less for C.M.V.
IgM antibodies and for ANA positive results. IgM gammopathy was more
prevalent in women who aborted less than five times than those aborted
more than five times.
HLA-B12 was more prevalent in age group 26 to 30 years, but HLAB17
more prevalent in age group 19 to 25 years C.M.V. IgG antibodies
seropositive results were more prevalent at age group 3Uo 35 years, but
C.M.V. IgM antibodies were more at 26 to 30 years age group.
ANA positive test results were more prevalent at age group 19 to 25
years, also IgM gammopathy was more prevalent in this age group.
In case of C.M.V. IgG antibodies low socioeconomic patients were
more seropositive and also for C.M.V. IgM antibodies than high
socioeconomic level patients.
Rural patients were more positive for C.M.V. IgG and C.M.V. IgM
antibodies than urban patients.
Recommendations :
1- In this study it was found that the degree of HLA sharing can not
always be directly associated with habitual abortions. So it is not
recomended as a common investigation to do HLA typing and
sharing for these patients with their partners.
2- As the response of these patients for C.M.V. is lower than normal.
Other serological studies of these women should include
consideration of immune responses to other viruses such as other
herpes group viruses.
3- Screening patients for ANAis an important test and should be
done routinely. Also screening patients with other autoimmune
conditions such as:- rheumatoid arthritis, scleroderma, mixed
connective tissue disease, polymyositis, and dermatomyositis is
recommended.