الفهرس 
Materials and methodsOnly 14 pages are availabe for public view
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Abstract
The aetiology of preeclampsia is so far unknown nevertheless both clinical and experimental findings suggest
the possibility of immunogenetic factor Bolis at al. (1987).
The aim of this work is to evaluate some immunological
parameters associated with pre-eclampsia compared to normal
pregnant and normal non pregnant women.
Thirty four pre-eclamptic females were included in this
study, they were compared to forteen normal pregnant females,
also compared tOeten non pregnant females.
The following investigation were done for the three groups
- Studying the humoral mechanism through measurements of :
* Immunoglobuliqs (IgG, IgM, IgA and IgE)
* Complement C3 and C4
* Circulating immune complexes.
-Studying the cellular immune response through :
* Numerical evaluation of T-lymPhocytes by E-rosettes.
* Studying their function through.
Blast transformation.
MIF test.
The results obtained showed the fOllowing :
- Significant decrease in IgG in pre-eclamptics compared to
both normal pregnant and non pregnant.
- No significant difference in IgM, IgA, complement C3 and C4
and circulating immune complex between the tested groups.
- Significant increase in IgE in pre-eclamptics compared to
both normal pregnant and non pregnant groups.
- As regards the total nUmber of T-Iymphocytes as measured by
E-rosette methods.
Significant decrease in pre-eclampsia compared to normal
pregnant.
- Highly significant decrease compared to non pregnant.
As regards the blast transformation of T-IymPhocytes :
Significant decrease between pre-eclampsia and normal
pregnant.
Highly significant decrease between pre-eclampsia and
normal non pregnant women.
As regards the percentage of inhibition of migration there was :
Significant decrease between pre-eclampsia and both
pregnant and non pregnant groups.
- In conclusion, there was hyporesponsiveness of the immune
system in pre-eclampsia but it is not known whether these
result is due to pre-eclampsia itself or associated
phenomena with the disease, longtudinal stUdies for
patients during pregnancy and post partum period for
investigating both humoral and cellUlar immunity Would be advised