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Abstract
Hypertension is the most common medical disorder associated with
pregnancy. Pre-eclampsia con tinnes two thirds of cases of hypertension
with pregnancy. Hypertensive disorders complicating pregnancy are
common and along with haemorrhage and infection they form deadly
triadthat is responsible for a large number of maternal deaths.
Preliminary studies have suggested a possible therapeutic role of
nitric ox.ide donors in women with established pre eclampsia.
In the present study we compared the effects of tansdermal
glyceryl triniirate (GT ) with that of sublingual isosorbide dinitrate(lD)
in the acute control of hyperten ion in evere preeclapmsia,
This study was conducted on 50 pregnant women diagnosed as
severe pre-eclampsia and admitted to Obstetrics Department of Om
EL-Masrien Hospital. 25 patients were given jransdermal GT 10mg
patches for 16 h./day , this was the first group. The patients of the second
group has received ublingual ID 5mg. AU cases were ubiected to full
history laking, complete general and obstetric examination. The patients
were evaluated (SBP, DB?, pulse and AIR were measured) every 15
minutes through the first hour and every 4 hour during the first 24 hours
of treatment.