الفهرس 
Fas (CD95, Apo1)/Fas Ligand Apoptotic SystemOnly 14 pages are availabe for public view
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Abstract
A variety of biological functions are regulated through
extracellular signals. Amongst the best studied examples is growth
control, which is achieved by the regulatory function of glrOwthfactors,.
Proqrammed cell death (apoptcsis) is controlled in a similar fashion.
Apoptosis, firstly a morphologically de’fined process, isa highly
controlled type of cell death that plays a critical role in embryonic
development, deletion of aLAoreaclive T-cells and adult tissue
homoeostasis. There is increasing evidence thaI derangement of the
epoptotic program is the underlying cause of a series of diseases
including liver diseases. The deadly program can be initiated by ligand
binding to membrane bound receptors such as CD95, which is the most
prominent cell death inducing member of the Tumor necrosis factor
(TN’F) receptor superfamily. The core of the subsequently activated
intracellular machinery is formed by a set of proleases, namely
caspasss. Once activated, they orchestrate the complete destruction of
the cellular skeleton leadiing to the typical apoptotlc morphology.
(Schuchmann & Ga’lIe, 2001).
Tumor necrosis factor (TNFl. fibroblast-associated cell surface
(Fas) Ugand, and TNF-related apoptosis-inducing ligand (TRAIL), all
members of the TNF superfamily, are arguably the most potent inducers
of cell death. These cytokines induce cell death through sequential
recruitment by the death receptors TNFR1- associated death domain
protein (TRAOD), Fa.s-associateddeath domain protein (FADD), FADDlike
interleukin-1beta-converting enzyme (FLlCE), and downstream