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Abstract Corneal graft rejection e”” be consid”r ••d as one of the main causes of late graft failure. This 50 callea immune allograft re~ction. Fortionataly this allogr~ft reaction takes pl~Qe in a small percentage of gratted corneas. The ~lIcgraft reaction OCCurs usually ~fter a latent p~riod ranging from two ~eQks up to many year~. Thio; tim” i s needed for the i1l1Il1unreaction to be completed” How@ver, it may be as early as thr~@ days after regrafting due to the previow,; sellsiti~ation of the host to the same donor antigens. sensitization also, occurs after blood transfusion, pre9nancies arid other organ transplantation~” It is suggested that tissue typing e~pecial1y in thOSe hosts presynth.:lt.ized to the donor antigens or with vascl.Uarised recipient beds-hi9h r.i, Sk <;ases-W’i11 ,reduce much th~ rate of histo-inoornpatibility between the donor and recipient arid in tUJ:”’n will reduce the rate or rej~ction episoJes. It is better to avoid t.hi G reaction b@tore it oocurs by means of -”]5- 1- l:Iest se.lection of the. dorio r graft m...t•~rial as n;!’ilards the age of th~ donor, the cause - of d”’ath, acul~r pathology i~ presant, and reducing the interval bct”’een death 1l.J1d enucleation and transplantation AS mUQh as possible. ,2- Good storage and preservation of the donor rnat:e~ialor better, the usa of a ~res~ mat~rial. 3- 6iomicroscopic asseSSl1Ieht of the donor cornea to select tha grafts with competent endoth~lia1 cell count to be able to withstand any rejection @pi50de, if it occurs. 4- ~reatment of the donor graft by several means to reduc@ its ant ig~nici ty as by culture or placement in a high titre dntidonor serum. 5- The use of prophylactic steroids of suggested by BOIDe surgeons. The rate of OC~Orcnce of allograft reaction can be reduced by modification of surgical technique~ e.g the use of smallsl: grafts and less irritant ”lI\onofil”’lI1ent <nylon sutur~s. |